Abstract
Objective: Endocannabinoid system (ES) seems to be altered in patients with depression. Cardiorespiratory fitness (CRF) may be an interacting factor in the relationship between ES biomarkers and depressive symptoms in people diagnosed with depression. The aim was to study the role of CRF on the possible association between ES biomarkers and depressive symptoms in 73 adults diagnosed with depression. 
 Method: This study examine the outcomes of cardiorespiratory fitness and plasma levels of the lipid mediators; anandamide (AEA) and 2-arachidonoylglycerol (2-AG) sampled from 73 adults diagnosed with depression.
 Results: Patients with high CRF level had significant and inverse association among depressive symptoms and 2-AG serum levels (β: -0.013; 95% CI: -0.262 to -0.000; R²=22.6; P<0.001).
 Conclusions: Higher CRF levels could have a protective role on depressive symptoms by increases in 2-AG.
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