Role of cardiac progenitor cell-derived exosome-mediated microRNA-210 in cardiovascular disease.

Lirong Wang,Yaqian Yang,Junping Zhang,Ao Zhang,Yuan Zhuo,Yingyu Xie,Qiujin Jia,Chen Xinnong,Runteng Liu

doi:10.1111/jcmm.14562

Abstract

Cardiac progenitor cells are considered to be one of the most promising stem cells for heart regeneration and repair. The cardiac protective effect of CPCs is mainly achieved by reducing tissue damage and/or promoting tissue repair through a paracrine mechanism. Exosome is a factor that plays a major role in the paracrine effect of CPCs. By delivering microRNAs to target cells and regulating their functions, exosomes have shown significant beneficial effects in slowing down cardiac injury and promoting cardiac repair. Among them, miRNA‐210 is an important anoxic‐related miRNA derived from CPCs exosomes, which has great cardiac protective effect of inhibiting myocardial cell apoptosis, promoting angiogenesis and improving cardiac function. In addition, circulating miR‐210 may be a useful biomarker for the prediction or diagnosis of related cardiovascular diseases. In this review, we briefly reviewed the mechanism of miR‐210 derived from CPCs exosomes in cardiac protection in recent years.

Highlights

Cardiovascular disease (CVD) is still an important cause of human death, and its incidence is increasing year by year
Cardiac progenitor cells (CPCs) exosomes contain a variety of miRNAs, which have the effects of anti‐apoptosis, anti‐ fibrosis, promoting angiogenesis, reducing infarction area and scar
The results showed that the diameter of extracellular vesicles (EVs) secreted by CPCs was about 30‐90nm and had a typical lipid double‐layer structure,[10] which was similar in size and structure to exosomes

Summary

Introduction

Cardiovascular disease (CVD) is still an important cause of human death, and its incidence is increasing year by year. MiRNAs regulate cardiac functions by acting on them‐ selves or distant target cells through autocrine or paracrine, so as to play a role in the treatment of CVDs. CPCs exosomes contain a variety of miRNAs, which have the effects of anti‐apoptosis, anti‐ fibrosis, promoting angiogenesis, reducing infarction area and scar

Results

Conclusion