Abstract
Introduction: Prevention of post-partum hemorrhage (PPH) is a major issue due to its impact on maternal mortality and morbidity. Primary post-partum hemorrhage (PPH) is the leading cause of maternal mortality in low- income countries and the primary cause of nearly one quarter of all maternal deaths globally. Aim of the Study: The aim of this study was to assess the effect of carbetocin over oxytocin in consequence of PPH. Methods: This was a cross- sectional study conducted in the Department of Obstetrics and Gynecology at Chattogram Medical College Hospital (CMCH), Chittagong, Bangladesh during the period from March 2018 to February 2019.Study population was the patient (n=100) with the risk of develops primary PPH following cesarean section. Women fulfilling inclusion criteria was included in the study and divided into 2 groups- Experimental group (n=50 cases) received 100μg of IV carbetocin through intravenous route; Control group (n= 50 cases) received 10 IU oxytocin through intravenous route. Data collection was done by the researcher after taking the written consent. Statistical analyses were done by SPSS 23. Result: In total 100 patients from both the groups completed the study. In our study we found the mean age was 25.20±5.43 years in carbetocin group and 25.90±5.83 years in oxytocin group. Regarding obstetric indications in carbetocin group majority (28.0%) patients had prolonged labour, 13 (26.0%) P/H/O C/S, 9 (18.0%) obstructed labour. In oxytocin group majority (38.0%) patients had P/H/O C/S, 14 (28.0%) had obstructed labour and 8 (16.0%) had prolonged labour. In 2 hours post-operative mean pulse was found 71.6±7.3 beats/min in carbetocin group and 68.9±5.9 beats/min in oxytocin group. Conclusion: In our study, it can be concluded that Carbetocin is as effective and safe as Oxytocin in the prevention of PPH following caesarean section. Carbetocin is more heat stable than oxytocin which is of crucial importance to resource poor settings like us. .......
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