Abstract
Mice lacking smooth muscle calponin (also called basic calponin or calponin h1) expression displayed enhanced entopic bone formation in vivo, induced by recombinant human bone morphogenetic protein-2 (rhBMP-2) and an augmentation of the degree of osteoblastic differentiation of embryonic mesenchymal cells when they were stimulated by rhBMP-2. Calponin messenger RNA was shown to be expressed in developing and healing bone tissues. An examination of the skeletons of mutated mice showed increased postnatal bone formation characterized by an increase in the number of activated periosteal osteoblasts. These data revealed that calponin plays an important role in regulating the osteogenic differentiation of mesenchymal cells.
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