Abstract
Rat pituitary tissue was incubated in vitro and the release of ACTH was monitored by radioimmunoassay. The release of ACTH that occurred spontaneously from unstimulated tissue was uninfluenced by a 3-hr preincubation of the tissue in the absence of calcium. ACTH release stimulated by crude hypothalamic extracts, synthetic vasopressin, dibutyryl adenosine 3',5'- monophosphate (cyclic AMP) and theophylline was inhibited by incubating pituitary tissue in the absence of calcium. It is concluded that in vitro activation of ACTH release, but not spontaneous ACTH release, is a calcium-dependent phenomenon. If ACTH release is mediated by cyclic AMP, then calcium ion is required for the action of cyclic AMP and need not oppose its formation. (Endocrinology 87:426,1970
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
