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Abstract
We studied the influence of Ca(2+) on exocytosis induced by hypotonic shock using the fluorescent dyes acridine orange FM1-43 and FM2-10. It was shown using acridine orange that lowering osmolarity to 230 mOsm/L induces exocytosis both in calcium-containing and calcium-free media. By contrast, we were able to demonstrate calcium dependence of exocytosis using styryl dyes. Lowering osmolarity leads to an increase of neurotransmitter release in a calcium-independent manner. Thus, our data suggest that hypotonic swelling induces calcium-independent exocytosis. Calcium influx mediated by stretch channels is able to switch mode of exocytosis from "kiss and run" to full fusion.
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