Role of calcium channel blocker in excessive mast cell degranulation

Sagarika Datta

doi:10.32553/ijmbs.v5i7.1981

Abstract

Here, I present a case of a female patient, age 45 years, for whom the uncontrolled mast cell degranulation created many issues related to allergy like, skin rash, itching, breathing discomfort, frequent throat infection, GERD, migraine, fibromyalgia, peripheral neuropathy, depression, anxiety disorder, constipation etc. For the patient, it was observed that calcium channel blockers seem to control the unnecessary and uncontrolled mast cell degranulation. CCB seemed to have a role to play in mast cell degranulation.

Highlights

Background: Here, I present a case of a female patient, age 45 years, for whom the uncontrolled mast cell degranulation created many issues related to allergy like, skin rash, itching, breathing discomfort, frequent throat infection, GERD, migraine, fibromyalgia, peripheral neuropathy, depression, anxiety disorder, constipation etc
Antihistamine and montelukast tablets used to help for allergy and rashes, corticosteroid inhalers used to help for the breathing discomfort and azithromycin tablets used to help for throat infections
On using Flunarizine, it was previously seen that the need for H1 Blocker and H2 Blocker are much less

Summary

Background

The patient suffered from food allergy, pollen, dust, hot, cold allergy, and frequent throat infection from childhood. Antihistamine and montelukast tablets used to help for allergy and rashes, corticosteroid inhalers used to help for the breathing discomfort and azithromycin tablets used to help for throat infections. All these are for time being relief and not for treating the root cause. The patient started showing problems of anxiety disorder and neuropathy pain and more severe migraine. As a whole patient needed to deal with allergy, asthma, migraine, fibromyalgia, depression, GERD, RLS, weak muscle all problems together.

Discussion

Not applicable