Abstract
Diabetes Mellitus is one of the most common major public health problems having worldwide distribution. Depending on the etiology of diabetes mellitus, factors contributing to hyperglycemia may include; reduced insulin secretion, decreased glucose usage and increased glucose production. Recently, there in increasing evidence that an ongoing cytokine induced acute phase response which is sometimes called low grade inflammation, but part of a widespread activation of the innate immune system, is closely involved in the pathogenesis of type 2 diabetes mellitus and associated complications such as dyslipidemia and atherosclerosis. Elevated circulatory inflammatory markers such as C-reactive protein and interleukin-6 predict the development of type 2 Diabetes mellitus and several drugs with anti-inflammatory properties both lower both acute phase reactants and glycemia and possible decrease the risk of developing type 2 diabetes mellitus. In this mini review article, we aimed to systematically review the role of C-reactive protein (CRP) as inflammatory marker with increased risk of type 2 diabetes as well the relation with type 1 diabetes
Highlights
C-reactive protein (CRP) is a biochemical substance which produced from hepatocyte and level used to increases in serum due to inflammatory challenge in the body
The purpose of the present review study was to determine any positive association between CRP concentrations and plasma glucose levels in diabetic patient and what is the role of
Present evidence supports the notions that atherosclerosis develops in parallel with type 2 diabetes [39] with both conditions showing the common antecedent of activated innate immunity, but like hyperglycemia and possibly some other manifestation of type 2 diabetes such as obesity, microangiopathy once present, would presumably further enhance inflammation[40]
Summary
C-reactive protein (CRP) is a biochemical substance which produced from hepatocyte and level used to increases in serum due to inflammatory challenge in the body. Shamim Shaikh Mohiuddin et al Role of C-Reactive Protein (CRP) as a Marker of an Acute Phase Response in Case of Diabetes Mellitus: A Mini Review. C-reactive protein (CRP) which used to consider as a marker of systemic inflammation, is emerging as an independent risk factor for cardiovascular disease [2][3]. A few prospective studies have declared that increased CRP levels are an independent risk factor for diabetes mellitus in future prospective [6][7]. All these studies and findings indicate that CRP levels in peripheral blood are very much associated with glucose levels, it remains unclear whether a relationship exists between CRP levels and plasma glucose levels in the pre-diabetic range. The purpose of the present review study was to determine any positive association between CRP concentrations and plasma glucose levels in diabetic patient and what is the role of
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
