Abstract
Publisher Summary This chapter describes the role of brain monoamines in male sexual behavior. The effects of p-chlorophenylalanine (PCPA) administration on the homo- and heterosexual behavior are suppressed in rats, rabbits and cats by 5-hydroxytryptophan, the direct precursor of serotonin. This amino acid also abolishes the spontaneous copulatory behavior of normal rats with receptive females. This inhibition is potentiated by inhibitors of extracerebral decarboxylase, suggesting that 5-HTP acts centrally. The monoamineoxidase inhibitor, pargyline, suppresses the spontaneous copulatory behavior of male rats with receptive females at the time when brain serotonin is maximally increased and inhibition, as well as serotonin accumulation, is prevented by PCPA. Marked homosexual mounting behavior has been observed in male rats after other treatments that lower brain serotonin, such as p-chloro-N-methyl-amphetamine and the intraventricular injection of 5,6 dihydroxytryptamine and furthermore, in testosterone-treated male rats, after different inhibitors of serotonin receptors such as mesorgydine, methysergide and Wa 335-BS . Inhibition of heterosexual copulatory behavior has been observed after the administration of LSD which is considered a direct stimulant of central serotonin receptors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
