Abstract
Benign recurrent intrahepatic cholestasis (BRIC) is an inherited self limiting cholestatic disorder. It is very rare and less common than its severe form, Progressive familial intrahepatic cholestasis (PFIC). Due to impaired canalicular biliary excretion, patients develop recurrent episodes of jaundice and intense pruritus with characteristic symptom free intervals. Most of the cases have a benign course and are managed symptomatically. Histopathological examination of liver biopsy is essential in cases of recurrent intrahepatic cholestasis to confirm the diagnosis. Here we report two cases of biopsy confirmed Benign recurrent intrahepatic cholestasis for its rarity.
Highlights
Benign recurrent intrahepatic cholestasis (BRIC) is an inherited cholestatic disorder due to impaired canalicular biliary excretion
Patients present with recurrent attacks of jaundice and intense pruritus.Asymptomatic period between icteric episodes is classical of BRIC
We report two cases of BRIC in a 23 years old male and a 15 years old female with histopathologic confirmation
Summary
Benign recurrent intrahepatic cholestasis (BRIC) is an inherited cholestatic disorder due to impaired canalicular biliary excretion. Patients present with recurrent attacks of jaundice and intense pruritus.Asymptomatic period between icteric episodes is classical of BRIC. Histopathological examination of liver biopsy shows centrizonal canalicular cholestasis without any inflammation or fibrosis. Due to its episodic and non progressive nature, patients are usually counseled and managed symptomatically. We report two cases of BRIC in a 23 years old male and a 15 years old female with histopathologic confirmation. Less than ten cases have only been reported so far in India with biopsy done in few cases
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
