Role of bioactive fatty acids in nonalcoholic fatty liver disease.

Eva Juárez-Hernández,Varenka J Barbero-Becerra,Norberto C Chávez-Tapia,Misael Uribe

doi:10.1186/s12937-016-0191-8

Eva Juárez-Hernández, Varenka J Barbero-Becerra + Show 2 more

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https://doi.org/10.1186/s12937-016-0191-8

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Journal: Nutrition journal	Publication Date: Dec 1, 2015
Citations: 176	License type: cc-by

Affiliation: Hospital Médica Sur

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesity, anti steatosic and anti-inflammatory effects. The combination of these forms of fatty acids—according to dietary type, daily intake and the proportion of n-6 to n-3 fats—can compromise hepatic lipid metabolism. A chemosensory rather than a nutritional role makes bioactive fatty acids possible biomarkers for NAFLD. Bioactive fatty acids provide health benefits through modification of fatty acid composition and modulating the activity of liver cells during liver fibrosis. More and better evidence is necessary to elucidate the role of bioactive fatty acids in nutritional and clinical treatment strategies for patients with NAFLD.

Highlights

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by deposition of fat in hepatocytes of patients with no history of excessive alcohol consumption
NAFLD is associated with obesity, type 2 diabetes, hypertension and dyslipidemia; is considered the hepatic manifestation of metabolic syndrome, and it has a strong association with nutritional factors [2]
Bioactive fatty acids encompasses a range of structures, from simple saturated fatty acids to complex molecules derived from various biological compounds, playing important roles in

Summary

Introduction

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by deposition of fat in hepatocytes of patients with no history of excessive alcohol consumption. Fats have been considered to be sources of energy and components of biological membranes, research over recent years demonstrate a diverse array of biological activities associated with fatty acids, their derivatives and other types of lipid compounds. Bioactive fatty acids encompasses a range of structures, from simple saturated fatty acids to complex molecules derived from various biological compounds, playing important roles in Dietary fatty acids are involved in hepatic lipogenesis and might play a dual role in the pathogenesis of liver steatosis as they are involved in their development and in preventing or reversing hepatic fat accumulation. Patients with NASH, claim a diet richer in fat and poorer in complex carbohydrates and protein that the general population [6]

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