Role of B-cell receptors for B-cell development and antigen-induced differentiation.

Juan Carlos Yam-Puc,Kai-Michael Toellner,Lingling Zhang,Yang Zhang

doi:10.12688/f1000research.13567.1

Juan Carlos Yam-Puc, Kai-Michael Toellner + Show 2 more

Open Access

https://doi.org/10.12688/f1000research.13567.1

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Journal: F1000Research	Publication Date: Apr 6, 2018
Citations: 34	License type: CC BY 4.0

Affiliation: University of Birmingham, Institute of Immunology

Abstract

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.

Highlights

B cells, the antibody-producing cells, have a protagonist role in the immune response
This leads to phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM) by the first kinase in the B-cell receptor (BCR) signaling pathway, primarily LYN
DAG represents a classic activator of protein kinase C (PKC) isotypes which regulate the mitogen-activated protein kinase (MAPK) family; the overall result of these processes drives activation of the B cell, antigen presentation, cytokine production, and cell proliferation and differentiation[17,18,19]

Summary

Introduction

B cells, the antibody-producing cells, have a protagonist role in the immune response. B cells develop through several well-characterized stages, ending with the expression of surface IgM and IgD class Ig molecules, which, in association with Igα and Igβ, form the B-cell receptor (BCR) for the antigen[5,6]. BCR is activated by binding of the antigen This leads to phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM) by the first kinase in the BCR signaling pathway, primarily LYN (part of the src-kinase family). DAG represents a classic activator of PKC isotypes which regulate the mitogen-activated protein kinase (MAPK) family (extracellular signal-regulated kinase [ERK], c-Jun NH2terminal kinase [JNK/SAPK], and p38 MAPK); the overall result of these processes drives activation of the B cell, antigen presentation, cytokine production, and cell proliferation and differentiation[17,18,19]. We will discuss the effects of BCR signaling during B-cell development and after the encounter with the antigen

B cells Three major populations of mature B cells have been described in mice

Fagraeus A

Cooper MD

15. MacLennan IC

22. Avrameas S

Findings

26. Baumgarth N