Abstract
Role of Autologous Platelet-Rich Plasma in Wound Healing in Obese Patients Undergoing Elective Caesarean Delivery (Prospective study).
Highlights
Skin is the largest organ in vertebrates, comprising 10% of the total body mass and covers the entire surface area
Patients and Methods Setting: This study will be performed on 140 cases for cesarean delivery who will be admitted to minia university hospital. 2- Funding. 3- Ethical issue: The protocol of the study was approved by ethical committee of gynecology and obstetrics department Minia University On 7\1\2019. 4- Study Design: This will be a balanced, randomized, prospective study that will be performed on 140 cases for cesarean delivery who will be admitted to Minia university hospital. 5- Plan of study: A research protocol including methods, considered outcomes, sample size calculation, and ethical considerations was produced prior to the initiation of the study
Informed consent was obtained from all participants and the study was registered to have a number. patients were divided into two treatment groups: (a) Study group (PRP group): wounds were cleaned with normal saline, and Platelet-rich plasma (PRP) solution was injected in subcutaneous tissue of wound after closure of the sheath. (b) Control group: the wounds were cleaned with normal saline 6- Participants: All cesarean sections was carried out in Minia university hospital and under the supervision of the supervisors, and all of the patients was received the same preoperative intravenous antibiotic
Summary
Skin is the largest organ in vertebrates, comprising 10% of the total body mass and covers the entire surface area. Platelet-rich plasma (PRP) can be defined as an autologous blood product containing a platelet concentration higher than the baseline level of 150,000--350,000platelets/mL (mean1⁄4250,000) within whole blood Platelets play a central role in tissue regeneration. They function in hemostasis, construction of new connective tissue, and revascularization. These growth factors aid in the process of wound healing by laying collagen matrix, fibroblast proliferation and early maturation of collagen. Based on this background autologous platelet growth factors in the form of platelet rich plasma started in wound healing
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