Role of ATP-Small Heat Shock Protein Interaction in Human Diseases.

Sandip K Nandi,Ashis Biswas,Saswati Soumya Mohapatra,Alok Kumar Panda,Ayon Chakraborty,Shivani Rathee,Subhashree Barik,Ipsita Roy

doi:10.3389/fmolb.2022.844826

Abstract

Adenosine triphosphate (ATP) is an important fuel of life for humans and Mycobacterium species. Its potential role in modulating cellular functions and implications in systemic, pulmonary, and ocular diseases is well studied. Plasma ATP has been used as a diagnostic and prognostic biomarker owing to its close association with disease’s progression. Several stresses induce altered ATP generation, causing disorders and illnesses. Small heat shock proteins (sHSPs) are dynamic oligomers that are dominantly β-sheet in nature. Some important functions that they exhibit include preventing protein aggregation, enabling protein refolding, conferring thermotolerance to cells, and exhibiting anti-apoptotic functions. Expression and functions of sHSPs in humans are closely associated with several diseases like cataracts, cardiovascular diseases, renal diseases, cancer, etc. Additionally, there are some mycobacterial sHSPs like Mycobacterium leprae HSP18 and Mycobacterium tuberculosis HSP16.3, whose molecular chaperone functions are implicated in the growth and survival of pathogens in host species. As both ATP and sHSPs, remain closely associated with several human diseases and survival of bacterial pathogens in the host, therefore substantial research has been conducted to elucidate ATP-sHSP interaction. In this mini review, the impact of ATP on the structure and function of human and mycobacterial sHSPs is discussed. Additionally, how such interactions can influence the onset of several human diseases is also discussed.

Highlights

Adenosine triphosphate (ATP) is termed as energy currency of cells owing to its high energy phosphate bonds
These findings indicate that M. leprae possesses an ATP binding protein, which evokes the possibility of using ATP competitive antibiotics/inhibitors in the context of effective treatment of leprosy
HSP16.3 is considered as an important immuno-dominant antigen, which belongs to the family of small heat shock protein and exhibits chaperone activity (Verbon et al, 1992; Chang et al, 1996; Zhang et al, 2018)

Summary

Introduction

ATP is termed as energy currency of cells owing to its high energy phosphate bonds. It is used by several enzymes and structural proteins to mediate cellular processes. Apart from this, peptides derived from the sHSP (α-crystallin), act as mini chaperone and inhibit epithelial cell apoptosis and prevent cataract in experimental rat models, which can be of immense therapeutic use (Nahomi et al, 2013). ROLE OF ATP-sHSP INTERACTION WITH PROLIFERATION OR PREVENTION OF HUMAN DISEASES

Results

Conclusion