Abstract

Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior

Highlights

  • Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior

  • The aim of this work was to analyze associative networks that describe genetic interactions between genes/proteins involved in neuro­ nal apoptosis, differentially expressed genes and genes with polymorphisms in grey rats with aggressive be­ havior

  • It was shown that polymorphic and differentially expressed genes were statistically significantly overrepresented among ge­nes interacting with neuronal apoptosis genes (p-value < 0.01)

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Summary

Системная биология человека и животных

Роль генов апоптоза в контроле агрессивного поведения, выявленная с помощью комбинированного анализа ассоциативных генных сетей, экспрессионных и геномных данных по серым крысам с агрессивным поведением. Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior. The aim of this work was to analyze associative networks that describe genetic interactions between genes/proteins involved in neuro­ nal apoptosis, differentially expressed genes and genes with polymorphisms in grey rats with aggressive be­ havior. Как цитировать эту статью: Брагин А.О., Сайк О.В., Чадаева И.В., Деменков П.С., Маркель А.Л., Орлов Ю.Л., Рогаев Е.И., Лаврик И.Н., Иванисенко В.А. How to cite this article: Bragin A.O., Saik O.V., Chadaeva I.V., Demenkov P.S., Markel A.L., Orlov Yu.L., Rogaev E.I., Lavrik I.N., Ivanisenko V.A. Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior. Эти данные говорят в пользу того, что генетически обусловленная агрессия у крыс

Human and animal systems biology
Результаты и обсуждение
Анализ генов нейронального апоптоза

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