Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.

Abstract

The purpose of this study was carried to evaluate the protective and anti-inflammatory effect ofginger against metalaxyl toxicity induced liver damage and oxidative stress in rats. Forty two malealbino rats were divided into three equal groups. Group I (normal group): rats administered distilledwater. Group II (metalaxyl exposed group): rats received metalaxyl 1/10 LD50 (130 mg/kg b.wt)orally three times per weeks for 8 weeks. Group III (metalaxyl + ginger treated group): rats receivedmetalaxyl (130 mg/kg b.wt) and treated with ginger (100 mg/kg b.wt/day/orally). The obtainedresults showed significant increase in serum hepatic function enzymes (ALT, AST and ALP)activities, hepatic tissue L-MDA levels and inflammatory biomarkers (MPO and IL-6) in metalaxylexposed rats. However, activities of liver tissue antioxidant enzymes (SOD, CAT) and GSHconcentration were markedly decreased. Administration of ginger with metalaxyl exposed ratscaused significant improvement of all previous parameters towards its normal ranges. These resultssuggested that, ginger treatment may have a protective effect against liver damage and oxidativestress in rats through free radical scavenging and anti-inflammatory activity as well as regeneratingendogenous antioxidant defense system mechanisms.