Role of Anti-Tissue Transglutaminase IgA Antibody in Aborted Women Infected with Toxoplasma Gondii in Association with Latent Coeliac Disease

Shukryia Shadhan Chyad

doi:10.5101/nbe.v9i4.p306-313

Abstract

Role of Anti-Tissue Transglutaminase IgA Antibody in Aborted Women Infected with Toxoplasma Gondii in Association with Latent Coeliac Disease

Highlights

Toxoplasma gondii is an obligate intracellular protozoan parasite that is capable of infecting a variety of intermediate hosts including humans
Aborted women had a higher level of both AtTg IgA and anti-Toxo IgG antibodies than the control group, with a highly significant (P < 0.01) increase, while IgM had a higher level but no significant increase
This result suggested that there was a relationship between aborted women having Toxoplasma infection and AtTg antibodies, which might indicate there was a latent coeliac disease associated with pregnancy leading to spontaous abortion

Summary

Introduction

Toxoplasma gondii is an obligate intracellular protozoan parasite that is capable of infecting a variety of intermediate hosts including humans. An association between CD and reproductive abnormalities was first made in 1970 when Morris et al described three patients with untreated CD and infertility, all of whom became pregnant after initiating a GFD Since this case report, the literature addressing complications of CD in women, especifically the rate of infertility, length of fertile life span, perinatal complications and adverse pregnancy outcomes, has been inconsistent [5]. Though there are conflicting data regarding the relative risk of infertility and other reproductive complications, undiagnosed CD should be considered as an etiology in patients with recurrent complications of pregnancy, and these women should be screened for serologic markers. Recurrent abortions, stillbirths or intrauterine growth retardation could have subclinical CD, which can be detected by serological screening tests. Statistical analysis was done by using ChiSquare and one way ANOVA tests in SPSS statistical program

Results and Discussion

Conclusions

Conflict of Interests