Role of annexin A1 in early diagnosis of lung cancer

Abstract

Background: The prevalence of lung cancer has shown an increase over the last few years which cause both health and economic burden. The biopsy is the gold standard tool for disease diagnosis, but it is usually not accepted by the patients due to its invasive nature. The use of non-invasive biomarkers is now attaining a great interest in diagnosis. Aim of the work: Assess the role of Annexin A1 in bronchoalveolar lavage and serum in the early diagnosis of lung cancer. Patients and methods: This study included 39 patients into two groups; group A (cases with lung cancer) and group B (cases with non-malignant lung lesions). All subjects were submitted to history taking and thorough full physical examination and laboratory analysis. Bronchoalveolar lavage (BAL) was performed in the cases within the two groups. Both serum and BAL levels of annexin A1 were assed in all cases. Results: In the current study, the level of annexin A1 in the serum and BAL were statistically significantly higher in the malignant group as compared with the non-malignant group (P 0.001).