Role of angiotensin in normal blood pressure regulation.

Abstract

Antiangiotensin II plasma induced transitory hypotension in rats when 0.2 ml was injected intravenously in normal males (either awake or anaesthetized), into binephrectomized females or into some males which had been nephrectomized 18–22 or 42–53 hours previously. Antiangiotensin II did not affect the blood pressure of male rats when given between 24 and 26 hours after nephrectomy. Antiangiotensin resulted in a 10–200 fold increase in the dose of angiotensin required to produce a measurable change in blood pressure, and also significantly reduced reactivity to l-noradrenaline.