Role of Angiogenic and Inflammatory Signal Pathways in Psoriasis.

Abstract

Dysregulation of any of the factors involved in the inflammatory response is important in the development of disease, and failure to resolve this response leads to chronic inflammation. Psoriasis is a common immune-mediated chronic inflammatory skin disease characterized by epidermal hyperplasia, parakeratosis, dermal inflammatory cell infiltration, and angiogenesis (Nestle et al., 2009). There is increased growth and altered differentiation of keratinocytes in both the epidermal granular and cornified layers in psoriasis (Perera et al., 2012).