Abstract

Administration of specific oligonucleotide selectively inhibiting alpha(2A)-adrenoceptor gene expression into the locus coeruleus of male rats for 3 days activated the hypothalamic-pituitary-adrenal system, which was manifested in a rise of blood plasma corticosterone content in rats with normal and hypertrophied (after castration) adrenal glands. These data indicate that alpha(2A)-adrenoceptors of the locus coeruleus are involved in the regulation of basal plasma corticosterone content.

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