Abstract

In this study, we investigated the participation of adrenergic neurotransmission in angiotensin II- (ANGII)-induced water intake and urinary electrolyte excretion by means of injection of the α 1-, α 2-, and β-adrenoceptor antagonists and ANGII into the medial preoptic area (MPOA) in rats. Prazosin (an α 1-adrenergic antagonist) entagonized the water ingestion, Na +, K + and urine excretion induced by ANGII, whereas yohimbine (an α 2-adrenergic antagonist) enhanced the Na +, K + and urine excretion induced by ANGII. Propranolol (a nonselective β-adrenoceptor blocker) antagonized the water ingestion and enhanced the Na +, and urine excretion induced by ANGII. Previous treatment with prazosin reduced the pressor responses to ANGII, whereas yohimbine had opposite effects. Previous injection of propranolol produced no effects in the pressor responses to ANGII. These results suggest that the adrenergic neurotransmission in the MPOA may actively participate in ANGII-induced dipsogenesis, natriuresis, kaliuresis and diuresis in a process that involves α 1-, α 2-,andβ-adrenoceptors.

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