Abstract
BackgroundAdiponectin is a protein hormone secreted by adipocytes. AimThe aim of present review is to enlist them all, and mention their significance in obesity, which helps researchers in drug discovery and future medicine. Material and methodsThe last 20 years data has been searched and studied to mention their current role in obesity treatment and ailments of disease. Results and conclusionAdiponectin exert its action through receptors AdipoR1, AdipoR2, T-cadherin. In muscle AdipoR1 is exhibit, while in liver AdipoR2 is mainly exhibit. AMPK and PPARα pathway in liver and skeletal muscle are magnified by adiponectin. Adiponectin show many function like expand fatty acids oxidation, control glucose level and manage receptor activity. Circulating level of adiponectin is lower in case of obesity, insulin resistance and other metabolic disorder. In this review we will focus on role of adiponectin and its receptors in metabolic disorder obesity.
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