Abstract
Lipid metabolism is frequently up-regulated in cancer cells and is related to tumor growth and malignancy. Particularly, de novo synthesized fatty acids are important in several cellular processes. Acyl-CoA synthetases (ACS) are key enzymes for conversion of the fatty acids to acyl-CoA, an essential step in utilization of the fatty acids. In glioma cells, some of the ACS isozymes are overexpressed and play a critical role in their growth and survival. In addition, inhibition of ACS or lipogenesis induces or enhances glioma cell death. Collectively, these observations suggest that ACS could not only be markers of the cancer but also be potential therapeutic targets.
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