Abstract
Platelet products contain both ABO antigen bound to platelets and anti-ABO isoagglutinins in the liquid portion. ABO incompatible plasma in a platelet product can cause significant hemolysis. At the same time, platelets which are ABO incompatible with the patient's plasma can cause smaller platelet count increments. In addition, though platelets do not bear Rh antigens, residual red cells contaminating a platelet unit can express Rh antigens. Though Rh incompatibility is not an immediate concern, sensitization of women to Rh antigens can be a concern for future pregnancies. Ideally, all patients should receive ABO identical platelets, but this is difficult to accomplish. Nevertheless, for certain patient groups ABO and Rh identical platelets should be provided if at all possible. The failure to use identical platelets in these groups can have grave consequences.
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