Abstract
Background: Pyroptosis is a newly recognized form of cell death. Emerging evidence has suggested the crucial role of long non-coding RNAs (lncRNAs) in the tumorigenesis and progression of ovarian cancer (OC). However, there is still poor understanding of pyroptosis-related lncRNAs in OC.Methods: The TCGA database was accessed for gene expression and clinical data of 377 patients with OC. Two cohorts for training and validation were established by random allocation. Correlation analysis and Cox regression analysis were performed to identify pyroptosis-related lncRNAs and construct a risk model.Results: Six pyroptosis-related lncRNAs were included in the final signature with unfavorable survival data. Subsequent ROC curves showed promising predictive value of patient prognosis. Further multivariate regression analyses confirmed the signature as an independent risk factor in the training (HR: 2.242, 95% CI: 1.598–3.145) and validation (HR: 1.884, 95% CI: 1.204–2.95) cohorts. A signature-based nomogram was also established with a C-index of.684 (95% CI: 0.662–0.705). Involvement of the identified signature in multiple immune-related pathways was revealed by functional analysis. Moreover, the signature was also associated with higher expression of three immune checkpoints (PD-1, B7-H3, and VSIR), suggesting the potential of the signature as an indicator for OC immunotherapies.Conclusion: This study suggests that the identified pyroptosis-related lncRNA signature and signature-based nomogram may serve as methods for risk stratification of OC. The signature is also associated with the tumor immune microenvironment, potentially providing an indicator for patient selection of immunotherapy in OC.
Highlights
Pyroptosis is a newly recognized form of cell death
A total of 4,222 pyroptosis-related long non-coding RNAs (lncRNAs) were identified by Pearson correlation test, and subsequent univariate
Cox regression and Kaplan-Meier curves were performed to determine the prognostic value of each lncRNA in the training cohort, suggesting 71 prognostic pyroptosisrelated lncRNAs
Summary
Pyroptosis is a newly recognized form of cell death. Emerging evidence has suggested the crucial role of long non-coding RNAs (lncRNAs) in the tumorigenesis and progression of ovarian cancer (OC). There is still poor understanding of pyroptosis-related lncRNAs in OC. Ovarian cancer (OC) is a lethal gynecologic malignancy among all gynecological tumors [1]. Surgery is recognized as the first-line treatment for OC; 4 patients out of 5 are unable to receive surgery because of advanced disease. The recognition of high- and low-risk patient groups may help individualize treatments, improving patient prognosis. Immunotherapies improve patient prognosis of several cancers [3], there is currently no significant breakthrough in the development of immunotherapy in treating OC during the decade. A promising indicator is needed to screen patients with OC who may benefit from certain immunotherapies
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
