Abstract
BackgroundThe FTO gene has recently become one of the most extensively investigated genes associated with body mass and has been shown to play a role in cardiovascular diseases as well. The aim of the current study was to investigate the effect of a common variant of FTO gene, rs9939609 in obese and coronary heart disease (CHD) patients of Pakistan and investigate whether it has any influence on the serum biochemical parameters.MethodsA total of 970 samples (295 obese, 425 CHD and 250 controls) were genotyped using TaqMan allelic discrimination assay. Serum total cholesterol, HDL-C and triglycerides were measured using spectrophotometric methods. LDL-C was calculated by Friedwalds equation. Statistical analysis was done by SPSS version 22.ResultsResults showed moderately high minor allele frequency (MAF) in obese and CHD cases as compared to controls (obese = 0.381 CAD = 0.361 and controls = 0.286). The variant was significantly associated with obesity and CAD (obesity odds ratio (OR) = 1.54, confidence interval (CI) = 1.07–2.21, p = 0.0009; CHD OR = 1.43, CI = 1.02–2.01, p = 0.004) in Pakistan. The risk allele did not show a significant association with any of the lipid trait tested (p > 0.05) but a strong association was observed with plasma glucose levels (obese p = 0.001, CAD p = 0.014, controls p = 0.019).ConclusionIn conclusion, the variant was associated with obesity and CAD in the studied subjects and its possible effect may involve the blood sugar metabolism but not serum lipid chemistry.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-016-0200-0) contains supplementary material, which is available to authorized users.
Highlights
The FTO gene has recently become one of the most extensively investigated genes associated with body mass and has been shown to play a role in cardiovascular diseases as well
Asian population is more susceptible to heart diseases and a 50 % higher prevalence of cardiovascular diseases has been reported in South Asians [6]
Keeping in view the importance of this variant in energy metabolism and contradictory results reported so far, we aimed to investigate the association of the FTO rs9939609 T > A singlenucleotide polymorphism (SNP) in Pakistani obese, Coronary heart disease (CAD) patients and control subjects and observe the effect of this variant on selected biochemical parameters
Summary
The FTO gene has recently become one of the most extensively investigated genes associated with body mass and has been shown to play a role in cardiovascular diseases as well. The aim of the current study was to investigate the effect of a common variant of FTO gene, rs9939609 in obese and coronary heart disease (CHD) patients of Pakistan and investigate whether it has any influence on the serum biochemical parameters. Obesity, defined as excessive accumulation of body fat, is a complex disorder whose pathogenesis involves both environmental and genetic factors. A complex disorder, is a strong predisposing risk factor for several other diseases, like diabetes, hypertension and CAD [1]. The mortality rate is increasing in developing countries and the disease burden is likely to be doubled by 2020 in these countries [5].
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