Abstract
Abstract Among the 5-HT1 receptors, 5-HT1B/D subtypes have been attributed to the vasocontractile response to serotonergic agonists. Some studies have shown that mainly 5-HT1B receptors mediate the vasocontractile response to 5-HT1B/D receptor agonists. In this study we examined the presence and involvement of 5-HT1B and 5-HT1D receptors and the role of the signalling molecules such as G proteins, cAMP, and inositol phosphates in the vasocontractile response induced by the 5-HT1B/D receptor agonist sumatriptan in common carotid artery (CCA).
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