Abstract
To explore the role of 5-HT receptor subtypes in controlling aversion, we measured the effect of 5-HT 1A and 5- HT 2 A 2 C receptor agonists microinjected into the dorsal periaqueductal gray (DPAG) of rats on aversive behavior induced by electrical stimulation of the same brain area. The 5-HT 1A agonists 8-OH-DPAT (4–16 nmol) and BAY-R-1531 (4–16 nmol) raised the threshold of aversive electrical stimulation in a dose-dependent way. Similarly, microinjection of the 5- HT 2 A 2 C agonist DOI (4–16 nmol) increased the aversive threshold in a dose-dependent way. In contrast, the 5-HT 2C agonist mCPP (16 and 32 nmol) was ineffective. Previous intra-DPAG administration of the 5-HT 1A receptor blocker NAN-190 (40 nmol) antagonized the antiaversive effect of 8-OH-DPAT (8 nmol), whereas pretreatment with the 5-HT 2A receptor blocker spiperone (10 nmol) antagonized the effect of DOI (16 nmol). Spiperone also counteracted the effect of 8-OH-DPAT and NAN-190 counteracted the effect of DOI. These results indicate that activation of 5-HT 1A and 5-HT 2A receptors inhibits aversion in the DPAG and that both receptors have to be functional for the expression of each one's activation to occur.
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