Abstract
In severe anemia, the oxygen-carrying capacity of blood is reduced, and adequate oxygen delivery to tissues is maintained by increasing the cardiac output, 1 Brannon ES Merrill AJ Warren JV et al. The cardiac output in patients with chronic anemia as measured by the technique of right atrial catheterization. J Clin Invest. 1945; 24: 332 Crossref PubMed Google Scholar , 2 Roy SB Bhatia ML Mathur VS et al. Hemodynamic effects of chronic severe anemia. Circulation. 1963; 28: 346 Crossref PubMed Scopus (78) Google Scholar , 3 Cropp GJA Cardiovascular function in children with severe anemia. Circulation. 1969; 39: 775 Crossref PubMed Scopus (20) Google Scholar by more complete deoxygenation of arterial blood, and, at least at altitude, by hyperventilation. 4 Cropp GJA Hemodynamic responses to oxygen breathing in children with severe anemia. Circulation. 1969; 40: 493 Crossref PubMed Google Scholar , 5 Cropp GJA Ventilation in anemia and polycythemia. Canad J Physiol Pharmacol. 1970; 48: 382 Crossref PubMed Scopus (6) Google Scholar This paper discusses how decreases in tissue PO2 and increases in red cell 2,3-diphosphoglycerate (DPG) concentrations contribute to the maintenance of normal oxygen supplies in the resting, anemic dog.
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