Abstract
This study aims to investigate the utility of 18F-fluoro-ethyl-tyrosine (18F-FET) positron emission tomography in surgical decision making in suspected glioma. A retrospective review of patients undergoing 18F-FET positron emission tomography was performed. Previously published thresholds for maximum tumor background ratios (TBRs) were used for quantitative analysis. Forty-seven patients were included in the study, of whom 15 had confirmed glioma and 7 had a confirmed alternative diagnosis. 18F-FET showed significantly higher uptake in high-grade glioma than in nonglioma. Lesions with TBRmax >2.5 should be considered suspicious for glioma and biopsy considered. Threshold TBRmax >3.0 is useful for differentiating high-grade glioma from low-grade glioma. This may be a particularly useful tool for directing management in eloquent areas, such as brainstem glioma.
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