Abstract
In acute experiments on anesthetized cats, the selective σ-opiate receptor agonist DSLET has a pronounced antiarrhythmic effect on ischemic heart rhythm disturbances. This effect is probably related to inhibition of the sympathetic heart rhythm regulation, because the antifibrillation effect of DSLET is not mediated via the vagus nerves, but on the other hand DSLET considerably modulates cardiac adrenoreactivity.
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