Abstract

Carbohydrate-rich components released from fractions of aggregated and protein aggregate-free γ-globulins decreased the cytotoxicity of natural killer cells in relation3H-uridine-labeled standard human K562 erythroblasts. In a dose of 0.1 μg/ml, these components decreased activity of natural killer lymphocytes by 57% and 42%, respectively. The data suggest that γ-globulin-associated fractions containing carbohydrate components are involved in the regulation of human natural killer activity.

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