Abstract
The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma without high-grade transformation (HT). We retrospectively reviewed 115 consecutive patients with histopathologically confirmed gastric MALT lymphoma without HT who underwent pretherapeutic F-18 FDG PET/CT. Kaplan–Meier and Cox proportional-hazards regression analyses were used to identify independent prognostic factors for disease free survival (DFS) among 13 clinical parameters and three PET parameters. In two of 115 patients (1.7%), the clinical stage appeared higher according to F-18 FDG PET/CT. In univariate analysis, Helicobacter pylori (HP) infection (P = 0.023), treatment modality (P < 0.001), and stage including PET/CT (P = 0.015) were significant prognostic factors for DFS. In multivariate analysis, only treatment modality was an independent prognostic factor (P = 0.003). In conclusion, F-18 FDG PET/CT played an important role in enabling upstaging of patients with gastric MALT lymphoma without HT. F-18 FDG PET/CT may have a prognostic role in gastric MALT lymphoma without HT by contributing to better staging.
Highlights
The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/ computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma without high-grade transformation (HT)
There is a lack of evidence for the usefulness of F-18 FDG PET/CT in indolent lymphoma, as it is associated with high false positive rates and cost[32]
Because a high percentage of gastric MALT lymphoma was not accompanied by HT, study of the clinical role of F-18 FDG PET/CT in gastric MALT lymphoma without HT is needed
Summary
The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/ computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma without high-grade transformation (HT). In a previous study of primary gastric lymphoma, maximum standardized uptake values (SUVmax) of gastric DLBCL had a higher SUVmax and a worse prognosis for the overall survival than gastric MALT lymphoma[6]. It elucidated that gastric MALT lymphoma without HT had a lower fluorine-18-fluorodeoxyglucose (F-18 FDG) avidity than that of gastric MALT lymphoma with HT. A small number of patients with gastric MALT lymphoma were upstaged by F-18 FDG PET/CT4,14
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