Abstract
Role for TRPA1 receptor channels in trigeminal afferent activation and neuropeptide release from rat cranial dura mater
Highlights
TRPA1 receptor channels are activated by environmental irritants and by endogenous mediators released during inflammatory conditions (McMahon & Wood 2006,)
Acrolein significantly stimulated calcitonin generelated peptide (CGRP) release from the dura mater within 5 min and increased meningeal blood flow. Both responses were suppressed by the TRPA1 inhibitor HC030031
To further examine the role of TRPA1 receptor activation in processes presumably associated with headache generation, we investigated the effects of the TRPA1 agonist acrolein on functions involved in meningeal nociception using four different rat models
Summary
TRPA1 receptor channels are activated by environmental irritants and by endogenous mediators released during inflammatory conditions (McMahon & Wood 2006,). Results Acrolein did not elicit discharges in meningeal Aδ- or C-fibres in the hemisected cranial preparation and did not change the discharge activity of second order neurons with meningeal receptive fields in anaesthetized animals.
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