Role for fatty acid binding protein in the regulation of hepatic lipogenesis by dietary linoleic acid

Abstract

The effect of added dietary ethyl palmitate or ethyl linoleate on hepatic lipogenic enzymes and the amount of hepatic fatty acid binding protein was examined in meal-fed rats. Dietary linoleate reduced the activities of fatty acid synthetase, glucose-6-phosphate dehydrogenase, NADP-malic enzyme, ATP-citrate lyase, and the amount of fatty acid binding protein compared to rats fed a fat-free or palmitate supplemented diet. The possible role of fatty acid biding protein in the regulation of lipogenesis by dietary fat is discussed.