Abstract
Hypoxia environment plays an important role in the pathogenesis of multiple myeloma such as stimulating angiogenesis, increasing bone destructiong, epithelial-mesenchymal transition and drug resis-tance. Thus, there are many therapeutic strategies targeting the hypoxic environment of multiple myeloma, such as hypoxia-activated prodrug and molecular targeting inhibitors. Targeting the hypoxic environment is a promising therapy for multiple myeloma in the future. Key words: Hypoxia-inducible factor 1; Multiple myeloma; Neoplasms; Metabolism
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