ROLE AND PLACE OF TIOCETAM IN STRATEGY OF NEUROPROTECTION IN SEVERE CCT AND ISCHEMIC STROKE

Abstract

The question about the possible ways of pharmacological correction of the second damage of cerebral tissue in brain ischemia, trauma and hemorrhage is a topical one. Trophic dysregulation, biochemical and functional differentiation of neurons are the universal component of nervous tissue damage pathogenesis. Reparative therapy is directed on the improvement of plasticity of healthy tissue which surrounds the area of ischemic-damaged brain, on activation of polysynaptic connections formation, on the increase of density of receptors and traditionally includes nootropic preparations. The comatose state of patient is a contraindication to application of these agents, because they provide a stimulating action. The application of Tiocetam (combination of piracetam with thyotriazolinum) is perspective in solution of this problem. In intensive therapy of acute cerebral insuffi ciency caused by the severe craniocerebral trauma or brain stroke a problem of determination of terms of beginning of treatment by Tiocetam and criteria of choice of adequate dose of this preparation is a topical one. The method of determination of Tiocetam adequate dose is developed on the basis of comparison of methods of estimation of impairment of consciousness on Glasgow Coma Scale and integral quantitative analysis of level of disorganization of EEG-patterns with research of brain responsiveness to Tiocetam introduction.