Role and effects of n-acetylcysteine in rat killer (rodenticide) poisoning

Abstract

Introduction:- Rodenticide is one of the pesticides and heterogeneous substances used to kill rats. Rodenticide poisoning is a major health problem in Asian countries, particularly the mode of self-poisoning, prevalent in India. It causes hepatotoxicity and no antidote has been found. N-acetylcysteine (NAC) is a powerful antioxidant and used in the treatment of acetaminophen-induced hepatotoxicity. The main objectives of this study were to determine the role of NAC in liver impairment rodenticide poisoning patients. Methods:- Patients who ingested rat killer poison and age >15 years were included in the study. Patients having jaundice, liver disease, and age <15 years were excluded from the study. Results:- Out of 50 patients. 27 (54%) were females and 23 (46%) were males. Age group between 21-30 years contributes the highest 20 (40%). The majority of types of rodenticide compounds consumed by patients were pasted 29 (58%) and less than four hours 26 (52%) patients were admitted. and 7 (14%) patients died. Conclusion:-In liver impairment rodenticide poisoning patients, early use of NAC shows a significant result and the rate of recovery is also high. N-acetylcysteine, Rodenticide poisoning, Liver impairment.&nbsp