Abstract
The etiology of erythema nodosum is not specific, since it is believed that it may be caused by almost any infectious disease. Apparent outstanding sources are rheumatic fever, tuberculosis, syphilis, and infections caused by the gonococcus and meningococcus. Histologic examination of the lesions of erythema nodosum shows that there are dilatation of the capillaries and extravasation of serum, leukocytes, and erythrocytes into the surrounding tissues. The bruised appearance assumed on healing is due to the disintegration of red blood cells. The eruption consists of poorly defined, nodular lesions varying in diameter from a few millimeters to 5 or 6 cm. The lesions are prone to appear on the shin but may occur on any of the extremities or on the buttocks. The overlying skin is smooth, shiny, and generally of a rose red color. Ulceration seldom takes place; the nodules appear in crops, last from a few days to several weeks, and slowly disappear (1). The eruption is usually preceded by mild constitutional sy...
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