Abstract
Anthropogenic environmental changes arising from settlement and agriculture include deforestation and replacement of natural vegetation by crops providing opportunities for pathogen spillover from animals to humans. This study aimed to investigate the prevalence of rodent-borne virus infections in seven rural settlements from Midwestern Brazil. Of the 466 individuals tested 12 (2.57%) were reactive for orthohantavirus and 3 (0.64%) for mammarenavirus. These rural settlers lived under unfavorable infrastructure, socioeconomic disadvantages, and unsanitary conditions, representing a risk for rodent-borne infections. Development of public policies towards the improvement of health, sanitation and awareness of rodent-borne diseases in improvised camps and settlements is imperative, in order to reduce morbidity and mortality caused by these diseases.
Highlights
Human behavior, especially spatial expansion of agriculture, has been implicated as drivers of some recent emerging disease events that had important impact on human health.[1]
Before they own the land, they live in camps, where living conditions are unfavorable.[4]. In addition, many families live in rudimentary housing, devoid of piped water, electricity, selective garbage collection, conditions that favors proliferation and increases chances of contact with rodents.[4,5,6] In this context of social vulnerability and environmental degradation, this study aimed to investigate the prevalence of rodent-borne viruses infections in rural settlers from Brazil
Human infections caused by hantaviruses and mammarenaviruses are associated with the natural cycle of these viruses, and transmission usually occurs by inhalation of aerosolised rodent excreta.[7]. Brazil occupies most of the eastern portion of South America, supporting several biomes with multiple natural ecosystems that account for the reported regional differences and temporal trends of hantavirus pulmonary syndrome (HPS).(8) To date, more than 2,000 HPS cases have been reported and six hantavirus genotypes have been identified as pathogenic to humans in Brazil: Juquitiba, Araraquara, Castelo dos Sonhos, Laguna Negra, Anajatuba and Rio Mamore viruses
Summary
Especially spatial expansion of agriculture, has been implicated as drivers of some recent emerging disease events that had important impact on human health.[1].
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