Abstract
To ascertain whether Uncaria gambir (W. Hunter) Roxb.'s ethanol extract can reduce diabetes complications due to its antioxidant activity. Sprague Dawley rats with diabetes were induced by streptozotocin. Twenty-five rats were divided into four groups: the negative control (k-), which received 1% Na-CMC; the extract group (P1, P2, and P3) with doses of 50 mg/Kg BW, 75 mg/Kg BW, and 100 mg/Kg BW for 21 days. Rats received therapy for 21 days before being fasted the following morning and sacrificed. Measure the level of Hydrogen peroxide, Malondialdehyde (MDA), changes in Catalase activity, and Superoxide Dismutase (SOD) levels in blood plasma used spectrophotometric. In comparison to diabetic rats receiving of Na-CMC, and ethanol extract for 21 days resulted in noticeably greater Catalase enzyme activity and a decrease in levels of Malonaldehyde and Hydrogen Peroxidas However, it was unable to boost superoxide dismutase activity. Uncaria gambir (W.Hunter) Roxb. extract has the ability to prevent diabetic complications in diabetic rats due to its antioxidant activity and previously noted antihyperglycemic effects
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