ROC Curve in Evaluation of Diagnostic Value of Serum 25-hydroxyvitamin-D for PCOS with Depression.

Abstract

The objective of this study was to apply receiver operating characteristic (ROC) curve to evaluate diagnostic value of serum 25-hydroxyvitamin-D [25-(OH)D] for polycystic ovarian syndrome (PCOS) combined with depression. Serum 25-(OH)D level was determined in 106 PCOS patients. Beck depression scale (BDI) and ROC curve were used to assess the objective. Results showed that there were 40 cases (37.74%) in combined depression group, and 66 (62.26%) in non-combined depression group. Number of patients with depression family history and BDI score in combined depression group were higher than those in non-combined depression group (p=0.002 and p<0.001, respectively). Serum 25-(OH)D level in combined depression group was lower than that in non-combined depression group (p<0.001). Area under ROC curve for prediction of PCOS combined with depression by serum 25-(OH)D was 0.829 (95% CI=0.746-0.911). Clinical point value of diagnosis of serum 25-(OH)D was 10.89 μg/L. Sensitivity was 75% and specificity was 78.8%. Key Words: Serum, 25-hydroxyvitamin-D [25-(OH)D], Polycystic ovarian syndrome (PCOS) , Depression, Receiver operating characteristic (ROC) curve.