Abstract
The aim of this work was to discover the robustness of combined wet milling process to determine the interval of the Mel (meloxicam) amount and to predict the degree of crystallinity of the milled samples using DSC and XRPD measurements. The samples had the poly(vinyl alcohol) (PVA) as the stabilizing agent. By increasing the amount of the Mel, its crystallinity increased and close correlation was found between the degree of crystallinity and the Mel amount. To achieve the desired particle size range (100–500 nm), the Mel amount should be changed between 10.0 and 17.5% (w/w) and a PVA concentration should be used between 5.0 and 4.58% (w/w). In this specified range, the degree of crystallinity of Mel will be changed between 20 and 45%. The crystallinity of Mel investigated by DSC and XRPD did not show any significant difference at 95% significance level. During the milling process to predict the amorphous content of the active agent, the DSC method can be suggested for the fast quantification of the degree of crystallinity.
Highlights
Dry and wet milling technologies as disintegration methods are conventionally and commonly used in the pharmaceutical industry [1, 2]
The aim of this work was to discover the robustness of combined wet milling process to determine the interval of the Mel amount and to predict the degree of crystallinity of the milled samples using Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) measurements
The crystallinity of Mel investigated by DSC and XRPD did not show any significant difference at 95% significance level
Summary
Dry and wet milling technologies as disintegration methods are conventionally and commonly used in the pharmaceutical industry [1, 2]. Drugs which belong to Class II of BCS (Biopharmaceutical Classification System) have low water solubility and high permeability; their bioavailability can increase with the decrease in particle size to the nanosize range, resulting in a high specific surface and a fast dissolution rate. Amorphization of active agent can occur due to the high energy impact [3, 4]. Amorphization is a well-known possibility to enhance the dissolution rate of drugs with low water solubility. Due to the lack of crystalline structure and the crystal lattice breaking force, less energy is needed for solubilization. Additional stabilization is needed for the preservation of the amorphous form from recrystallization [5,6,7]
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