Abstract
Objective. This study aimed to evaluate the robustness of propofol combined with sevoflurane in patients undergoing laparoscopic radical nephrectomy and its influence on immune function during perioperative period. A total of 140 patients who underwent laparoscopic nephrectomy in the Department of Oncology of our hospital from January 2018 to January 2020 were divided into the control group and the study group by the random number table method, with 70 cases in each group, who were given sevoflurane anesthesia and sevoflurane combined with propofol anesthesia, respectively. The anesthesia effect and perioperative immune function of the two groups of patients were compared. No remarkable difference was observed in the extubation time, breathing recovery time, and awakening time between the two groups; the extubation coughing score and postextubation restlessness score of the study group were significantly lower than those of the control group; the postoperative renal function indexes of the two groups of patients were not considerably different; after treatment, the CD3+ (%), CD4+ (%), and CD4+/CD8+ of the two groups of patients decreased significantly, with a higher level in the study group. For patients undergoing laparoscopic radical nephrectomy, the combination of propofol and sevoflurane yields a promising outcome in enhancing the anesthesia results and improving the perioperative immune function.
Highlights
Known as renal cancer, is a malignant tumor originating from the urinary tubule epithelial system of the renal parenchyma, including various renal cell carcinoma subtypes coming of different parts of the urinary tubule [1, 2]
E immune system plays a key role in the occurrence, development, metastasis, and prognosis of tumors, and the impaired immune function caused by surgery would increase the risk of tumor recurrence or metastasis [7]
Studies have shown that intravenous anesthetics could exert a positive impact on the immune function of patients and in turn hinder the progression of malignant tumors [8]
Summary
Known as renal cancer, is a malignant tumor originating from the urinary tubule epithelial system of the renal parenchyma, including various renal cell carcinoma subtypes coming of different parts of the urinary tubule [1, 2]. Studies have proven that laparoscopic radical nephrectomy is equivalent to open radical nephrectomy in terms of tumor control. In this regard, the low-invasive laparoscopic radical nephrectomy has increasingly become acceptable in the field of urology [5, 6]. Studies have shown that intravenous anesthetics could exert a positive impact on the immune function of patients and in turn hinder the progression of malignant tumors [8]. Propofol, characterized by stable induction and speedy recovery from anesthesia, has been extensively used as an intravenous anesthetic in tumor removal surgery. Studies pointed out that in addition to anesthesia, propofol can protect the immune system function, thereby inhibiting the growth of tumor cells and improving the prognosis of patients. Its application has been frequently reported in malignant tumors such as breast cancer, glioma, and pancreatic cancer, yet there is a paucity of evidence on the impact of the immune function of patients undergoing
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