Robust-efficient fitting of mixed linear models: Methodology and theory

Abstract

In many areas of application mixed linear models serve as a popular tool for analyzing highly complex data sets. For inference about fixed effects and variance components, likelihood-based methods such as (restricted) maximum likelihood estimators, (RE)ML, are commonly pursued. However, it is well-known that these fully efficient estimators are extremely sensitive to small deviations from hypothesized normality of random components as well as to other violations of distributional assumptions. In this article, we propose a new class of robust-efficient estimators for inference in mixed linear models. The new three-step estimation procedure provides truncated generalized least squares and variance components' estimators with hard-rejection weights adaptively computed from the data. More specifically, our data re-weighting mechanism first detects and removes within-subject outliers, then identifies and discards between-subject outliers, and finally it employs maximum likelihood procedures on the “clean” data. Theoretical efficiency and robustness properties of this approach are established.