Robust optimization of cardiovascular stents: a comparison of methods

Abstract

Modern engineering design contains both creative and analytic components. This paper discusses the design process and illustrates links between design optimization and conceptual design through the re-design of a cardiovascular stent. A comparison is presented of two methods for design improvement: genetic algorithms (GA) and model-based robust engineering design (RED). Computational fluid dynamics (CFD) models are used to generate measurements of the quality of competing designs based on the concept of dissipated power. Alternative performance measures are also discussed. Environmental noise is introduced into the analysis and consideration is given to the treatment of discrete and continuous design parameters. Improved designs are identified using both methods and verified with further CFD analyses, and the benefits of each method are discussed.