Robust controlled formation of Turing patterns in three-component systems.

Abstract

Over the past few decades, formation of Turing patterns in reaction-diffusion systems has been shown to be the underlying process in several examples of biological morphogenesis, confirming Alan Turing's hypothesis, put forward in 1952. However, theoretical studies suggest that Turing patterns formation via classical "short-range activation and long-range inhibition" concept in general can happen within only narrow parameter ranges. This feature seemingly contradicts the accuracy and reproducibility of biological morphogenesis given the stochasticity of biochemical processes and the influence of environmental perturbations. Moreover, it represents a major hurdle to synthetic engineering of Turing patterns. In this work it is shown that this problem can be overcome in some systems under certain sets of interactions between their elements, one of which is immobile and therefore corresponding to a cell-autonomous factor. In such systems Turing patterns formation can be guaranteed by a simple universal control under any values of kinetic parameters and diffusion coefficients of mobile elements. This concept is illustrated by analysis and simulations of a specific three-component system, characterized in absence of diffusion by a presence of codimension two pitchfork-Hopf bifurcation.