Abstract
Automation and robotics have become a staple in the biological manufacturing sector due to their ability to efficiently work without operator input. Industrial robotic arms present themselves as a valuable tool for biological manufacturing because of their ease of programming and flexibility. This paper represents the use of a benchtop robot and automation system capable of manufacturing in-syringe liquid drugs. An International Organization for Standardization (ISO) compliant robotic arm (Stäubli TX2-60), customized end-effector, syringe venting system, and Cartesian gantry platform were prototyped and integrated to create an automated solution for manufacturing cyclic olefin copolymer (COC) polymer syringes. A Siemens programmable logic controller (PLC) system is developed to interface with the robot and the Cartesian gantry platform. Automated filling of a tray of 50ml syringes is proven to be feasible. The process of stoppering a COC syringe using a customized venting tube is demonstrated. An automated gantry system is also demonstrated as a proof of concept for a complete manufacturing system.
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