Abstract
Measuringblood and platelet function is vital for the development and use of drugs thatcombat cardiovascular disease, such as anti-platelet drugs and other medicinesthat reduce the risk of thrombosis. We propose combining mass-produced microfluidicdevices with open-source robotic instrumentation to enable development of affordableand portable, yet high-throughput and high-performance haematological testing.A time- and distance-resolved fluid flow analysis by Raspberry Pi imagingintegrated with controlled sample addition and illumination, enablessimultaneous tracking of capillary rise in 120 individual capillaries within 5minutes. We showed that time-resolved microcapillary rise imaging permits bloodfunction measurement by measuring thrombin-triggered activation of globalhaemostasis. Thrombin stimulation slowed vertical fluid velocity, consistentwith a dynamic increase in viscosity. Microfluidic systems expandhaematological testing towards high-efficiency, multi-parameter blood analysisnecessary for understanding and improving cardiovascular health.
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